The maximum concentration travoprost free acid plasma levels achieved within 10-30 minutes of topical application . travoprost free acid is rapidly cleared from the plasma concentration over hours drops below the threshold of detection (less than 10 pg / ml). Free acid travoprost in humans has not been established because of its low concentration in plasma and the rapid clearance of the organism after topical drug application. The metabolism is the main route of elimination of travoprost free acid and travoprost. Systemic pathway parallel pathways of metabolism of endogenous prostaglandin chlorodehydromethyltestosterone wikipedia deutsch, are characterized by reduction of 13-14 double bond, oxidation of 15-hydroxyl group and a β-link upper oxidative cleavage of the side chain. The free acid travoprost and its metabolites are primarily excreted by the kidneys. No dose adjustment in patients with impaired hepatic function, drostanolone enanthate from weakly expressed to severe, and in patients with impaired renal function, from weakly expressed to severe (with creatinine clearance below 14 ml / min) not required.
Reduction of elevated intraocular pressure in: – open-angle glaucoma; – increased intraocular pressure.
Individual hypersensitivity to the drug chlorodehydromethyltestosterone wikipedia deutsch, children under 18 years, pregnancy and lactation.
In patients with aphakia; patients at break psevdofakiey posterior lens capsule, or in patients with anterior chamber IOL patients; in patients at risk of cystoid macular edema in patients at risk of developing iritis, uveitis.
Locally. 1 drop into the conjunctival sac eye (eye) 1 time per day in the evening. To reduce the risk of systemic side effects is recommended after instillation of the drug pinch nasolacrimal duct by pushing in its projection at the inner corner of the eye. If the dose was missed, the treatment should be continued with the next dose. The daily dose should not exceed 1 drop in the conjunctival sac 1 eye once a day. If the drug chlorodehydromethyltestosterone wikipedia deutsch is appointed as a substitute for another ophthalmic preparation turinabol for the treatment of glaucoma, the latter should be repealed, and the following day to start .
Local. In 10% of cases observed bloodshot eyes. In 1-10% of cases – punctate keratitis, eye pain, photophobia, eye irritation, foreign body sensation, dry eye, eye pruritus, conjunctival hyperemia. In 0.1-1% of cases – blurred vision, increased lacrimation, itching and erythema of eyelid, crusting on the edges of the eyelids. Systemic side effects. In 1-10% of cases – skin hyperpigmentation, discoloration of the skin. In 0.1-1% of cases -. Dry mouth, headache Side effects that do not have the frequency (post-marketing experience). Local. Macular edema, eye iris color change, darkening, thickening and lengthening eyelashes / or an increase in their number, eyelid skin darkening. Systemic side effects. Bradycardia, tachycardia, exacerbation of asthma, dizziness, ringing in the ears, increased prostate specific antigen side effects of famara, a violation of the hair growth.
There is currently no reported cases of overdoses. Symptoms: mucous membrane irritation of the eyes, conjunctival hyperemia or episclera. In the case of a local drug should wash your eyes with warm water overdose. In case of suspicion of the use of oral treatment of symptomatic medication.
Interaction with other drugs
Be used in combination with other topical ophthalmic preparations for reducing intraocular pressure. In this case, the interval between their use should be at least 5 minutes.
The may cause a gradual change in eye color by increasing the amount of brown pigment in the iris. This effect is detected predominantly in patients with mixed colored irises, eg, blue-brown, gray-brown, green-brown or yellowish-brown, which is explained by an increase in melanin content in the stromal melanocytes of the iris. This effect was also observed in patients with brown eye color. Usually brown pigmentation spreads concentrically around the pupil to the periphery of the iris, and the entire iris or parts of it may acquire a more intense brown color. The long-term effects on the melanocytes and the consequences of this effect are currently unknown . Changing the iris color occurs slowly and may go unnoticed for a number of months or years. After discontinuation of the drug was observed to further increase the amount of brown pigment, but has evolved color change may be irreversible. In the presence of nevus or lentigo on the iris were observed their changes under the influence therapy with chlorodehydromethyltestosterone wikipedia deutsch . The drug can cause darkening, thickening and lengthening eyelashes / or increase their number; rarely darkening of the eyelid skin. The mechanism of these changes is not currently installed. Prior to treatment, patients t3 dosage should be informed about the possibility of changing eye color. Treatment of only one eye can lead to permanent heterochromia. Necessary to avoid contact with skin, since in experiments on rabbits demonstrated, percutaneous absorption travoprost. Prostaglandins and prostaglandin analogs – biologically active substances that can be absorbed through the skin. Women during pregnancy, and women who plan to become pregnant, should avoid direct contact with substances containing prostaglandins. In case of contact with a large amount of the drug on the skin should immediately rinse the water area of the skin. Before using the product, contact lenses must be removed and set back no earlier than 15 minutes after application of the preparation. The product contains propylene glycol, which can cause irritation to the skin! The product contains macrogol glitserilgidroksistearat that can cause reactions on the part of the skin! Do not touch the tip of the dropper bottle to any surface to avoid contamination of the vial-dropper and its contents. The vial must be closed after each use.
Effects on ability to drive vehicles and management mechanisms
If the patient after treatment temporarily chlorodehydromethyltestosterone wikipedia deutsch reduced sharpness of vision, to its recovery is not recommended to drive and engage in activities that require attention.