Paracetamol is rapidly and completely absorbed after oral administration. The absolute bioavailability after oral administration is about 80% and is dose-dependent within the dose range of turinabol chlorodehydromethyltestosterone pct trail. It practically does not bind to plasma proteins, and its volume distribution of about 0.91 kg.
After of paracetamol plasma in healthy adults is about 2.3 hours, varying from 1.5 to 3.0 h. Paracetamol biotrasformatsii undergoes intense in the liver and its major metabolites are inactive and fenolsulfatnye glucuronide conjugates. The intermediate product of the metabolism of paracetamol are usually excreted by the kidneys in the form mercapturic acid and cysteine conjugates. Glutathione conjugate can be excreted in the bile, but in this case it is cleaved by intestinal peptidases and cleavage products are reabsorbed.
Chlorpheniramine maleate : After oral administration, it is almost completely absorbed and distributed in the tissues. Maximum plasma concentrations were reached in 2-3 hours after a single dose fasted 12 mg. In human urine chlorpheniramine found unchanged (35%) and monodemetilirovannye (20%) and didemetilirovannye (10%) metabolites. Chlorpheniramine and its demethylated metabolites are slowly excreted over time.
Dextromethorphan hydrobromide : Following oral administration of dextromethorphan is well absorbed but undergoes extensive first-pass metabolism in the liver, resulting in its plasma chlorodehydromethyltestosterone pct trail concentration is only 0.1 g / l after 0.5 h and the average maximum concentration of 2.5 hours after a single dose is 20 mg 1.8 mg / l. Dextromethorphan is extensively metabolized in the liver and about 50% of the dose is excreted by the kidneys within 24 hours. Excreted bowel less than 1% of the dose. About 8% of the dose is excreted unchanged by the kidneys for 6 hours. Phenylephrine hydrochloride : The absorption of phenylephrine after oral administration varies considerably, it is subjected to intensive first-pass metabolism. As a result, its systemic bioavailability is only 40% and the maximum plasma concentration is achieved 1-2 hours after ingestion. The volume of distribution of 200-500 L and the median T ½ of the plasma is about 2-3 hours. After intensive absorption Phenylephrine undergoes biotransformation in the gut wall. Following oral administration deaminiruetsya 24% phenylephrine, since most of the ingested drug is metabolized by sulfation even before reaching the liver.
Symptomatic treatment of colds, flu, SARS, infectious and allergic rhinitis (a feverish syndrome, pain, rhinorrhea).
: Hypersensitivity to the drug; concomitant use of tricyclic antidepressants, monoamine oxidase inhibitors (MAOIs), beta-blockers; deficiency of chlorodehydromethyltestosterone pct trail dehydrogenase; blood diseases; liver and / or kidney failure; angle-closure glaucoma; prostatic hyperplasia; Gilbert’s syndrome; arterial hypertension; hyperthyroidism; pheochromocytoma; diabetes; bronchial asthma; bronchitis; pregnancy; lactation;children, age (under 14 years).
angina pectoris, hypertrophic obstructive cardiomyopathy (GOKMP), advanced age.
Dosing and Administration
Inside, adults – one capsule every 4-6 hours, but not more than 4 capsules per day.
Admission as an antipyretic means no more than 3 days without consulting a doctor.
Side effect On the part of the cardiovascular system : hypertension. From the nervous system and sensory organs : dizziness, drowsiness, irritability, mydriasis, paresis of accommodation, increased intraocular pressure. Digestive system: dry mouth, epigastric pain, nausea, vomiting, hepatotoxic effect. On the part of hematopoiesis : anemia, thrombocytopenia, hemolytic anemia, aplastic anemia. From the urinary system : urinary retention, renal toxicity (papillary necrosis). Allergic reactions (including skin rash, pruritus, angioedema), bronchial obstruction.
symptoms (due to paracetamol, appears after taking more than 10-15 grams): pale skin, anorexia, nausea, vomiting, gepatonekroz, increased activity of “liver” transaminases, increased prothrombin time.
Treatment: gastric lavage, followed by the appointment of activated charcoal, symptomatic therapy.
Interaction with other drugs
Enhances effects of MAO inhibitors, sedatives, ethanol.
Antidepressants, antiparkinsonian agents, antipsychotics, phenothiazine derivatives increase the risk of urinary retention, dry mouth, constipation. Glucocorticosteroids increase the risk of developing glaucoma. Paracetamol reduces the effectiveness of uricosuric drugs.
Chlorpheniramine appointed simultaneously inhibitors and furazolidone, can lead to a hypertensive crisis, agitation, increase in temperature.
Tricyclic antidepressants increase the sympathomimetic effects,chlorodehydromethyltestosterone pct trail of halothane increases the risk of ventricular arrhythmias.
Decreases hypotensive effect of guanethidine, which in turn, increases the activity of alpha-adrenostmuliruyuschuyu phenylephrine.
During treatment should not take other medicines that contain substances that are part of the drug.
In persons suffering from chronic alcoholism, receiving therapeutic doses of the drug can cause severe hepatic insufficiency.
The period of treatment should refrain from the use of ethanol (development of hepatotoxicity ), car driving and other activities potentially hazardous activities that require high concentration and psychomotor speed reactions.