22 Sep

chlorodehydromethyltestosterone – bd 10

Mania in bipolar disorder recommended initial dose – 2 mg per day in one portion. If necessary, this dose may be increased to 2 mg per day, no more than a day. For most patients, the optimal dose is 6.2 mg per day. Conduct disorders in patients with mental retardation patients weighing 50 kg or more – the recommended initial dose – 0.5 mg once daily. If necessary, this dose may be increased to 0.5 mg per day, no more than a day.

For most patients, the optimal dose is 1 mg per day. However, preferred for some patients receiving 0.5 mg per day, whereas some require increasing doses up to 1.5 mg per day. Patients weighing less than 50 kg – The recommended initial dose – 0.25 mg once daily. If necessary, this dose may be increased by 0.25 mg per day, no more than a day. For most patients, the optimal dose is 0.5 mg per day. However, for some patients receiving preferable to 0.25 mg per day, while others need to increase the dose to 0.75 mg per day. Use chlorodehydromethyltestosterone – bd 10 in adolescents should be carried out under the constant supervision of a doctor. Use in children under 15 years old Not recommended.

Side effect On the part of the nervous chlorodehydromethyltestosterone – bd 10 system: insomnia, agitation, anxiety, headache, sometimes – drowsiness, fatigue, dizziness, impaired concentration, blurred vision, rarely – extrapyramidal symptoms (tremor, rigidity, hypersalivation, bradykinesia, akathisia, acute dystonia) , mania or hypomania, stroke (in elderly patients with predisposing factors), as well as hypervolemia (either due to polydipsia or because the syndrome of inappropriate secretion of antidiuretic hormone), tardive dyskinesia (involuntary rhythmic movements mainly language and / or persons) neuroleptic malignant syndrome (hyperthermia, muscle rigidity, instability of the autonomous functions, impaired consciousness and increasing creatine phosphokinase levels), violation of thermoregulation and seizures. From the digestive system: constipation, dyspepsia, nausea or vomiting, abdominal pain, increased activity of “liver” transaminases , dry mouth, hypo- or hypersalivation, anorexia and / or increased appetite, increased or decreased body weight. on the part of the cardiovascular system: sometimes orthostatic hypotension, reflex tachycardia, or increased blood pressure.

From the side of hematopoiesis: neutropenia, thrombocytopenia. From endocrine system: galactorrhea, gynecomastia, irregular menstruation, amenorrhea, weight gain, hyperglycemia and exacerbation of pre-existing diabetes. With the genitourinary system: priapism, erectile dysfunction, ejaculation disorder, anorgasmia, urinary incontinence. Allergic reactions: rhinitis, rash, angioedema, photosensitivity. For the skin: dry skin, hyperpigmentation, itching, seborrhea. Other: arthralgia.

 

Overdosing
Symptoms: drowsiness, sedation, depression of consciousness, tachycardia, hypotension, extrapyramidal disorder, in rare cases, lengthening the interval chlorodehydromethyltestosterone – bd 10 it is necessary to ensure a free airway to ensure adequate oxygenation and ventilation, gastric lavage (after intubation if the patient is not consciousness), and the appointment of activated charcoal in combination with laxatives.Symptomatic therapy directed at maintaining vital functions of the body.

The interaction with other drugs
Given risperidone has effect primarily on the central nervous system, it should be used with caution in combination with other drugs central action and alcohol.
Clozapine reduces risperidone clearance .
When using carbamazepine marked reduction in the concentration of the active antipsychotic fraction of risperidone in plasma. Similar effects may occur with other hepatic enzyme inducers.
Phenothiazines, tricyclic antidepressants and some β adrenoblokatory may increase plasma concentrations of risperidone, but this does not affect the concentration of the active antipsychotic fraction.
Fluoxetine can increase plasma concentrations of risperidone, but less concentration active antipsychotic fraction, so the dose of risperidone should be adjusted.
in the application of risperidone with other drugs that are highly bound to plasma proteins, clinically pronounced displacement of a drug from the plasma protein fraction is observed.
Antihypertensive medicines increase the severity of blood pressure reduction on the background risperidone.

Cautions transition from other antipsychotic therapy. In schizophrenia, chlorodehydromethyltestosterone – bd 10 the beginning of treatment with risperidone, we recommend gradually cancel the previous therapy, if clinically justified. If patients are transferred from the depot forms of therapy antipsychotics, risperidone it is recommended to start in place of the next scheduled injection. Periodically assess the need for continued therapy potivoparkinsonicheskimi drugs. In connection with the a-adrenoceptor blocking effect of risperidone, orthostatic hypotension can occur, especially during the initial dose adjustment. In the event of hypotension should consider lowering the dose. In patients with diseases of the cardiovascular system, as well as dehydration, hypovolemia, or cerebrovascular disorders, the dose should be increased gradually, as recommended (see. Dosage and administration).

The occurrence of extrapyramidal symptoms chlorodehydromethyltestosterone – bd 10 is a risk factor for the development of tardive dyskinesia. In case of signs and symptoms of tardive dyskinesia should consider abolishing all antipsychotics. In the event of a neuroleptic malignant syndrome, characterized by hyperthermia, muscle rigidity, instability of the autonomous functions, impaired consciousness and increased levels of creatine is necessary to cancel all antipsychotic drugs, including risperidone. In case of cancellation of carbamazepine and other inducers of “liver” enzymes risperidone dose should be reduced. Should Patients recommend to refrain from eating because of the possibility of weight gain. During the treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions, as well as the reception of alcohol.

22 Sep

oral-turinabol

Ingestion risperidone completely absorbed (regardless of the meal) and maximum levels of plasma concentration observed after 1-2 hours. Risperidone is metabolized with a oral-turinabol cytochrome to form , which has a similar pharmacological action .

Indications

  • schizophrenia (acute and chronic) and other psychotic states with productive and / or negative symptoms;
  • affective disorders in a variety of mental illnesses;
  • behavioral disturbances in patients with dementia with aggressive manifestation of symptoms (angry outbursts, physical violence), disorders of mental activity (agitation, delirium) or psychotic symptoms;
  • as adjuvant therapy in the treatment of mania in bipolar disorder;
  • as adjunctive therapy of behavior disorders in adolescents from 15 years and adult patients with reduced intellectual level or mental retardation, oral-turinabol in cases where destructive behavior (aggressiveness, impulsivity, autoaggression) is leading the clinical picture of the disease.

Contraindications Diseases of the cardiovascular system (chronic heart failure, myocardial infarction, conduction disorders of the heart muscle)

  • Dehydration and hypovolemia
  • cerebrovascular accidents
  • Parkinson’s disease
  • seizures (including history)
  • severe renal or hepatic insufficiency (see. dosing recommendations)
  • drug abuse or drug dependency (see. for dosage recommendations)
  • conditions that predispose to the development of tachycardia type
  • brain tumor, intestinal obstruction, acute cases of drug overdose, Reye’s syndrome (an antiemetic effect of risperidone may mask the symptoms of these conditions)

Application of pregnancy and lactation. Risperidone oral-turinabol safety in pregnant women has not been studied. If pregnancy can only be used if a positive effect justifies the potential risk. Because risperidone and 9-hydroxy-risperidone passes into breast milk, women using the drug should not breast-feed.

Dosing and Administration Oral-turinabol for sucking are fragile, they should not be forced through the foil packaging, as they can break. The package is opened by gently pulling the edge of the blister foil, marked by a point and remove the tablet, and then it should be put into the language immediately. Tablet turnibol begins to disperse in the mouth within seconds and can be swallowed without water and mix the drug in the mouth with food. Tablets should not be chewed or crack. Schizophrenia. Adults and children over 15 years.

Risperidone can be administered once or twice a day. Initial dose – 2 mg per day. On the second day, the dose should be increased to 4 mg per day. From this point the dose can either maintain the same level, either individually adjusted if necessary. Typically, the optimal dose is 4.6 mg per day. In some cases it may be justified by a slower increase in the dose and lower initial and maintenance doses. Doses greater than 10 mg per day did not show a higher efficiency compared to lower doses and may cause the appearance of extrapyramidal symptoms. Due to the fact that the safety of doses above 16 mg per day has not been studied, doses above this level can not be used. For information on the use of a drug for the treatment of schizophrenia oral-turinabol in children younger than 15 years no. Elderly patients. It is recommended methandienone initial dose of 0.5 mg per administration twice a day . The dosage can be individually increased by 0.5 mg twice per day to 1.2 mg twice a day. Liver and kidney diseases. It is recommended initial dose of 0.5 mg to receiving two times a day. This dose can be gradually increased to 1-2 mg twice daily intake.Abuse of drugs or drug dependency – the recommended daily dose -. 2-4 mg . Behavioral disorders in patients with dementia is recommended that the initial dose of 0.25 mg per reception twice daily (adequate dosage form should be used). If necessary dosage can be individually increased by 0.25 mg 2 times a day, no more than a day. For most patients, the optimal dose is 0.5 mg twice a day. However, some patients are shown receiving 1 mg 2 times a day. On reaching the optimum dose of the drug can be recommended once daily.

22 Sep

chlorodehydromethyltestosterone dosage of tylenol

Symptoms: drowsiness, sedation, depression of consciousness, tachycardia, hypotension, extrapyramidal disorder, in rare cases, lengthening the interval : it is necessary to ensure a free airway to ensure adequate oxygenation and ventilation, gastric lavage (after intubation if the patient is not consciousness), and the appointment of activated charcoal in combination with laxatives.Symptomatic therapy directed at maintaining vital functions of the body.
For the early diagnosis of possible cardiac arrhythmias need to begin chlorodehydromethyltestosterone dosage of tylenol monitoring as soon as possible. Careful medical supervision  monitoring is carried out to complete disappearance of symptoms of intoxication. There is no specific antidote.

The interaction with other drugs
Given risperidone has effect primarily on the central nervous system, it should be used with caution in combination with other drugs central action and alcohol.
Risperidone reduces the effectiveness  and other dopamine agonists.
Clozapine reduces risperidone clearance .
When using carbamazepine marked reduction in the concentration of the active antipsychotic fraction of risperidone in plasma. Similar effects may occur with other hepatic enzyme inducers.
Phenothiazines, tricyclic antidepressants and some β adrenoblokatory may increase plasma concentrations of risperidone, but this does not affect the concentration of the active antipsychotic fraction.
Fluoxetine can increase plasma concentrations of risperidone, but less concentration active antipsychotic fraction, so the dose of risperidone should be adjusted.
in the application of risperidone with other drugs that are highly bound to plasma proteins, clinically pronounced displacement of a drug from the plasma protein fraction is observed.
Antihypertensive medicines increase the chlorodehydromethyltestosterone dosage of tylenol severity of blood pressure reduction on the background risperidone.

Cautions transition from other antipsychotic therapy. In schizophrenia, the beginning of treatment with risperidone, we recommend gradually cancel the previous therapy, if clinically justified. If patients are transferred from the depot forms of therapy antipsychotics, risperidone it is recommended to start in place of the next scheduled injection. Periodically assess the need for continued therapy potivoparkinsonicheskimi drugs. In connection with the a-adrenoceptor blocking effect of risperidone, orthostatic hypotension can occur, especially during the initial dose adjustment. In the event of hypotension should consider lowering the dose. In patients with diseases of the cardiovascular system, as well as dehydration, hypovolemia, or cerebrovascular disorders, the dose should be increased gradually, as recommended (see. Dosage and administration).

The occurrence of extrapyramidal symptoms is a risk factor for the development of tardive dyskinesia. In case of signs and symptoms of tardive dyskinesia should consider abolishing all antipsychotics. In the event of a neuroleptic malignant syndrome, characterized by hyperthermia, muscle rigidity, instability of the autonomous functions, impaired consciousness and increased levels of creatine is necessary to cancel all antipsychotic drugs, including risperidone. In case of cancellation of carbamazepine and other inducers of “liver” enzymes risperidone dose should be reduced. Should chlorodehydromethyltestosterone dosage of tylenol recommend to refrain from eating because of the possibility of weight gain. During the treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions, as well as the reception of alcohol.

22 Sep

turinabol

The dosage turinabol can be individually increased by 0.5 mg twice per day to 1.2 mg twice a day. Liver and kidney diseases. It is recommended initial dose of 0.5 mg to receiving two times a day. This dose can be gradually increased to 1-2 mg twice daily intake.

Abuse of drugs or drug dependency – the recommended daily dose -. 2-4 mg . Behavioral disorders in patients with dementia is recommended that the initial dose of 0.25 mg per reception twice daily (adequate dosage form should be used). If necessary dosage can be individually increased by 0.25 mg 2 times a day, no more than a day. For most patients, the optimal dose is 0.5 mg twice a day. However, some patients primobolan enanthate are shown receiving 1 mg 2 times a day. On reaching the optimum dose of the drug can be recommended once daily. Mania in bipolar disorder recommended initial dose – 2 mg per day in one portion. If necessary, this dose may be increased to 2 mg per day, no more than a day. For most patients, the optimal dose is 6.2 mg per day. Conduct disorders in patients with mental retardation patients weighing 50 kg or more – the recommended initial dose – 0.5 mg once daily. If necessary, this dose may be increased to 0.5 mg per day, no more than a day. Fo turinabolr most patients, the optimal dose is 1 mg per day. However, preferred for some patients receiving 0.5 mg per day, whereas some require increasing doses up to 1.5 mg per day. Patients weighing less than 50 kg – The recommended initial dose – 0.25 mg once daily. If necessary, this dose may be increased by 0.25 mg per day, no more than a day. For most patients, the optimal dose is 0.5 mg per day. However, for some patients receiving preferable to 0.25 mg per day, while others need to increase the dose to 0.75 mg per day. Long-term use of risperidone in adolescents should be carried out under the constant supervision of a doctor. Use in children under 15 years is not recommended.

Side effect On the part of the nervous system: insomnia, agitation, anxiety, headache, sometimes – drowsiness, fatigue, dizziness, impaired concentration, blurred vision, rarely – extrapyramidal symptoms (tremor, rigidity, hypersalivation, bradykinesia, akathisia, acute dystonia) , mania or hypomania, stroke (in elderly patients with predisposing factors), as well as hypervolemia (either due to polydipsia or turinabol because the syndrome of inappropriate secretion of antidiuretic hormone), tardive dyskinesia (involuntary rhythmic movements mainly language and / or persons) neuroleptic malignant syndrome (hyperthermia, muscle rigidity, instability of the autonomous functions clenbuterol bodybuilding, impaired consciousness and increasing creatine phosphokinase levels), violation of thermoregulation and seizures.

From the digestive system: constipation, dyspepsia, nausea or vomiting, abdominal pain, increased activity of “liver” transaminases , dry mouth, hypo- or hypersalivation, anorexia and / or increased appetite, increased or decreased buy winstrol body weight. on the part of the cardiovascular system: sometimes orthostatic hypotension, reflex tachycardia, or increased blood pressure. From the side of hematopoiesis: neutropenia, thrombocytopenia. From endocrine system: galactorrhea, gynecomastia, irregular menstruation, amenorrhea, weight gain, hyperglycemia and exacerbation of pre-existing diabetes. With the genitourinary system: priapism, erectile dysfunction, ejaculation disorder, anorgasmia, urinary incontinence. Allergic reactions: rhinitis, rash, angioedema, photosensitivity. For the skin: dry skin, hyperpigmentation, itching, seborrhea. Other: arthralgia turinabol.

22 Sep

turinbol

Risperidone is an antipsychotic, also has a sedative, antiemetic and hypothermic effect. Risperidone is a selective monoaminergic antagonist with a pronounced affinity serotonergic and dopaminergic, also binds to alpha s and at slightly lower affinity  and turinbol adrenergic receptors. It has no affinity for holinoretseptorami. Antipsychotic effect due to blockade of dopamine  and Mesocortical mesolimbic system. Sedative effect due to blockade of adrenergic receptors of the reticular formation of the brain;antiemetic action – blockade of dopamine trigger zone of the vomiting center; hypothermic action -. blockade of dopamine receptors of the hypothalamus reduces productive symptoms (delusions, hallucinations), automatism. It causes minimal suppression of motor activity and to a lesser extent induces catalepsy than classic antipsychotics (neuroleptics). Balanced central serotonin antagonism of dopamine and may reduce the risk of extrapyramidal symptoms. Risperidone can cause dose-dependent increase in plasma prolactin concentrations.

 

Pharmacokinetics
Ingestion risperidone completely absorbed (regardless of the meal) and maximum levels of plasma concentration observed after 1-2 hours.
Risperidone is metabolized with  cytochrome , which has a similar pharmacological action . Risperidone and 9-hydroxy-risperidone are effective antipsychotic fraction. Subsequent metabolism of risperidone . Ingestion risperidone is excreted in the half-life of about 3 hours.
In most patients, the equilibrium concentration of risperidone is observed one day after the start of treatment. The equilibrium state of 9-hydroxy-risperidone in most cases achieved 3-4 days after initiation of treatment.
Risperidone plasma concentration of the drug dose proportional (within therapeutic doses).
Risperidone is distributed quickly in the body. The volume of distribution is 1-2 l / kg. The risperidone plasma associated with albumin and alpha-1 acid glycoprotein. Fraction risperidone is associated plasma protein of 88% and 77%, respectively, in the case of 9-hydroxy-risperidone.
Excreted by the kidneys – 70% (35-45% of them as a pharmacologically active fraction) and 14% in the bile. In single dose have high levels of the active plasma concentrations and a slower elimination in elderly patients and patients with poor kidney function.

Indications

  • schizophrenia turinbol (acute and chronic) and other psychotic states with productive and / or negative symptoms;
  • affective disorders in a variety of mental illnesses;
  • behavioral disturbances in patients with dementia with aggressive manifestation of symptoms (angry outbursts, physical violence), disorders of mental activity (agitation, delirium) or psychotic symptoms;
  • as adjuvant therapy in the treatment of mania in bipolar disorder;
  • as adjunctive therapy of behavior disorders in adolescents from 15 years and adult patients with reduced intellectual level or mental retardation, in cases where destructive behavior (aggressiveness, impulsivity, autoaggression) is leading the clinical picture of the disease.

Contraindications
: Hypersensitivity to the drug; lactation, children under 15 years of age (efficacy and safety have not been established). Precautions:

  • Diseases of the cardiovascular system (chronic heart failure, myocardial infarction, conduction disorders of the heart muscle)
  • Dehydration and hypovolemia
  • cerebrovascular accidents
  • Parkinson’s disease
  • seizures (including history)
  • severe renal turinbol or hepatic insufficiency (see. dosing recommendations)
  • drug abuse or drug dependency (see. for dosage recommendations)
  • conditions that predispose to the development of tachycardia type “pirouette” (bradycardia, electrolyte imbalance, concomitant drugs prolonging  interval)
  • brain tumor, intestinal obstruction, acute cases of drug overdose, Reye’s syndrome (an antiemetic effect of risperidone may mask the symptoms of these conditions)

Pregnancy and lactation. Risperidone safety in pregnant women has not been studied. If pregnancy can only be used if a positive effect justifies the potential risk.
Because risperidone and 9-hydroxy-risperidone passes into breast milk, women using the drug should not breast-feed.

Dosing and Administration Schizophrenia. Adults turinbol and children over 15 years. Risperidone can be administered once or twice a day. Initial dose – 2 mg per day. On the second day, the dose should be increased to 4 mg per day. From this point the dose can either maintain the same level, either individually adjusted if necessary. Typically, the optimal dose is 4.6 mg per day. In some cases it may be justified by a slower increase in the dose and lower initial and maintenance doses. Doses greater than 10 mg per day did not show a higher efficiency compared to lower doses and may cause the appearance of extrapyramidal symptoms. Due to the fact that the safety of doses above 16 mg per day has not been studied, doses above this level can not be used. For information on the use of a drug for the treatment of schizophrenia in children younger than 15 years no. Elderly patients. It is recommended initial dose of 0.5 mg per administration twice a day .