Symptoms: drowsiness, sedation, depression of consciousness, tachycardia, hypotension, extrapyramidal disorder, in rare cases, lengthening the interval : it is necessary to ensure a free airway to ensure adequate oxygenation and ventilation, gastric lavage (after intubation if the patient is not consciousness), and the appointment of activated charcoal in combination with laxatives.Symptomatic therapy directed at maintaining vital functions of the body.
For the early diagnosis of possible cardiac arrhythmias need to begin chlorodehydromethyltestosterone dosage of tylenol monitoring as soon as possible. Careful medical supervision monitoring is carried out to complete disappearance of symptoms of intoxication. There is no specific antidote.
The interaction with other drugs
Given risperidone has effect primarily on the central nervous system, it should be used with caution in combination with other drugs central action and alcohol.
Risperidone reduces the effectiveness and other dopamine agonists.
Clozapine reduces risperidone clearance .
When using carbamazepine marked reduction in the concentration of the active antipsychotic fraction of risperidone in plasma. Similar effects may occur with other hepatic enzyme inducers.
Phenothiazines, tricyclic antidepressants and some β adrenoblokatory may increase plasma concentrations of risperidone, but this does not affect the concentration of the active antipsychotic fraction.
Fluoxetine can increase plasma concentrations of risperidone, but less concentration active antipsychotic fraction, so the dose of risperidone should be adjusted.
in the application of risperidone with other drugs that are highly bound to plasma proteins, clinically pronounced displacement of a drug from the plasma protein fraction is observed.
Antihypertensive medicines increase the chlorodehydromethyltestosterone dosage of tylenol severity of blood pressure reduction on the background risperidone.
Cautions transition from other antipsychotic therapy. In schizophrenia, the beginning of treatment with risperidone, we recommend gradually cancel the previous therapy, if clinically justified. If patients are transferred from the depot forms of therapy antipsychotics, risperidone it is recommended to start in place of the next scheduled injection. Periodically assess the need for continued therapy potivoparkinsonicheskimi drugs. In connection with the a-adrenoceptor blocking effect of risperidone, orthostatic hypotension can occur, especially during the initial dose adjustment. In the event of hypotension should consider lowering the dose. In patients with diseases of the cardiovascular system, as well as dehydration, hypovolemia, or cerebrovascular disorders, the dose should be increased gradually, as recommended (see. Dosage and administration).
The occurrence of extrapyramidal symptoms is a risk factor for the development of tardive dyskinesia. In case of signs and symptoms of tardive dyskinesia should consider abolishing all antipsychotics. In the event of a neuroleptic malignant syndrome, characterized by hyperthermia, muscle rigidity, instability of the autonomous functions, impaired consciousness and increased levels of creatine is necessary to cancel all antipsychotic drugs, including risperidone. In case of cancellation of carbamazepine and other inducers of “liver” enzymes risperidone dose should be reduced. Should chlorodehydromethyltestosterone dosage of tylenol recommend to refrain from eating because of the possibility of weight gain. During the treatment should refrain from activities potentially hazardous activities that require high concentration and psychomotor speed reactions, as well as the reception of alcohol.